Funded Research
ACTIVE Grant Portfolio
Measuring the Impact of Racism on the HIV Epidemic in California (2024): CHRP awarded more than $900,000 to three investigators who will develop methods of measuring the impact of racism on HIV-STI related outcomes among communities in California that are highly impacted by HIV. The three studies will each focus on sexual and gender minority (SGM) persons of color; each of the study teams have lived experience in the communities they will work in; and one awardee is an early career stage investigator.
Community-Centered Demonstration Projects to Support Implementation of Long-Acting Injectable PrEP Adoption Across California (2024): CHRP has invested more than $9,000,000 in five outstanding projects that will each increase equity in provision of LAI PrEP across California. They will reach many distinct California geographies and priority populations, such as Fresno, Riverside and Kern Countiesy, persons with substance use disorders, and cis- and transgender women receiving syphilis treatment; and will employ non-traditional service delivery models including community pharmacists as PrEP providers. The “learning collaborative” model, community-based recruitment techniques, and acting upon policy research conducted by CHRP’s HIV Policy Research Centers are centerpieces of many of the new projects.
Social and Behavioral Intervention Pilot Studies to Support HIV Prevention and Care (2024): Methamphetamine use is a key driver of the HIV epidemic, with one in three HIV seroconversions among sexual and gender minority individuals reporting persistent use. CHRP is proud to sponsor an open-label pilot clinical trial to evaluate the feasibility, safety, and preliminary efficacy of ketamine-assisted psychotherapy to treat methamphetamineuse disorders among persons seeking treatment, and treatment and examining it’s impact on HIV-transmission risk behaviors. The PI is an early career stage investigator.
Basic Biomedical and Translational Science Discovery Initiative (2024): Applications for these biannual awards were newly restricted to early career stage investigators (ESI) with named mentors, and the quality of the applications received was exceptionally high. CHRP is investing $1,900,000 in seven ESIs who will forge new paths toward an HIV cure and improved HIV treatment via epigenetic modulation, chimeric antigen receptor engineering, probing new compartments of the HIV reservoir, and the interaction of HIV RNA with human DNA. Many will utilize emerging single-cell sequencing technologies, and three will leverage the Last Gift cohort, a unique California resource.
Community-Centered Research Collaboratives (2023): CHRP funded five community-centered collaborative research teams who will work to identify HIV-related syndemic outcomes that are important to that community, jointly create a research agenda to improve those outcomes, implement research projects to serve that agenda, and disseminate research results with and for that community.
Basic Biomedical Discovery Initiative (2022): We awarded seven grants to fund early-stage laboratory exploration aimed at understanding mechanisms of HIV prevention, treatment, or cure at the cellular or subcellular level. Learn more about these projects by clicking here (Basic Biomedical Sciences Research Awards).
Implementation Science (2021): CHRP awarded four grants to support HIV implementation science that have the potential to be scalable for sustained impact on the HIV epidemic in California.
Policy Research Centers (2021): We awarded three grants to fund statewide HIV Policy Research Centers. These multi-disciplinary, academic teams work in partnership with providers, consumers, advocates, and policymakers to conduct timely and impactful HIV policy research. The Centers are working to strengthen local, state and national capacity to enact HIV-relevant policies informed by objective and rigorous research.
Recently funded
Basic Biomedical Sciences Research (2020): We awarded nine grants to researchers at non-profit institutions across the state. These pilot awards supported early-stage laboratory explorations aimed at understanding mechanisms of HIV prevention, treatment, or cure at the cellular or subcellular level.
One Step Ahead Initiative (2018): We funded four highly visionary, investigator-initiated HIV research projects aimed at moving the field significantly forward.
Basic Biomedical Sciences Research (2016): CHRP selected nine investigators from various institutions across California as recipients of the 2016 Innovative, Developmental Exploratory Awards (IDEAs) in basic biomedical science. These include multiple projects focused on paths to a cure for HIV (viral latency, persistence, or reactivation), new hope for persons with HIV and cancer, and HIV epidemiology.
Disparities Research (2016): UCLA, UCSD, and UCSF have Centers for AIDS Research (CFARs) which conduct and evaluate innovative research for HIV/AIDS prevention and treatment. In April 2016, CHRP funded the creation of Disparities Cores at each CFAR that initiated projects focused on HIV/AIDS health disparities throughout California, a focus that the CFARs did not previously have.
Prevention and Linkage to Care Research (2012-2016): Pre-exposure Prophylaxis (PrEP) demonstration projects and studies focused on HIV testing and linkage to care as methods to reducing the epidemic.
Policy Research (2012): We funded two Collaborative HIV/AIDS Policy Research Centers to support research and policy analysis that addresses critical issues related to HIV/AIDS care and prevention in California. These centers comprised of multi-disciplinary teams of investigators working in partnership with consumers, advocates, and policymakers to conduct timely, policy-relevant research that strengthen local, state, and national HIV efforts. This research produced new knowledge that improved prevention and care services for affected persons and populations.